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From a personal standpoint, the beginning of 2009 has been fairly uneventful for me. I am almost over what has seemed like an endless cold, which I first contracted in January. It forced me to postpone a wisdom tooth extraction, which I suppose I will have to reschedule soon. I am still in post-Christmas shape, which means I need to do much more in the way of exercise. Fortunately, my family have kindly arranged for me to get a bicycle for my forthcoming birthday. With spring on the way and plenty of places to ride nearby, I hope to start improving my overall fitness.
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Sildenafil (Viagra), whose labeling was approved by the U.S. Food and Drug Administration (FDA) in March 1998, is the first oral medication to be marketed for the treatment of erectile dysfunction. Sildenafil inhibits the conversion of cGMP to guanosine monophosphate in the corpus cavernosum, thereby increasing the available concentration of cGMP. This reaction is largely catalyzed by the enzyme phosphodiesterase type 5. Sildenafil inhibits this enzyme, resulting in relaxation of the cavernosal smooth muscle.17 Sildenafil is absorbed rapidly, with peak plasma levels achieved within an hour. It undergoes hepatic metabolism and has a half-life of about four hours.
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Oral agents that act peripherally to induce smooth muscle relaxation of the corpora cavernosa. The most commonly used agents are sildenafil (Viagra), vardenafil (Levitra), and tadalafil (Cialis). Sildenafil was the first in this series of PDE inhibitors. These agents rely on the role of NO in inducing vasodilatation. NO relaxes smooth muscle by stimulating guanylyl cyclase activity, which raises the intracellular concentrations of the cyclic nucleotide cGMP, which, in turn, induces vasodilation.
Possible blindness due to nonarteritic anterior ischemic optic neuropathy and cilioretinal artery occlusion caused by PDE-5 inhibitors has been a concern. This is an extremely rare event, with only a handful of reported cases from the tens of millions of patients using PDE-5 inhibitor medications. This risk may be increased if the PDE-5 medication is misused or overdosed.
Decreased physical satisfaction during intercourse Fatigue
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My first-line ED treatment is Viagra. If Viagra doesn't work, I suggest using a vacuum erection device (VED or trying drug injection therapy. A third, highly effective treatment is the surgical implantation of a penile prosthesis. In order to get an idea about how the VED works, I have a patient watch an instructional video in my office. To experience the injectable medication, the man will undergo a test injection in the office that same day.
Erectile Dysfunction is defined as the inability to achieve or maintain an erection sufficient for mutually satisfying intercourse. Erectile Dysfunction impacts more than a man's sexual activity. The emotions and uncertainties that coincide with this condition often have a significant effect on a man's self-esteem, as well as and his relationship with his partner. Although the incidence of Erectile Dysfunction increases with age, it is not an inevitable result of aging. Erectile Dysfunction is a secondary condition linked to many medical conditions.
A. Two extremely compact hollow cylinders, which come in a variety of widths and lengths, are implanted within the penis. A small container that holds fluid for the cylinders is inserted in the lower part of the abdomen and a pump is implanted in the scrotum. The patient squeezes the pump several times, which transfers the fluid from the container to the inflatable cylinders, which then expand, widening and lengthening the penis. To get rid of the erection, the valve at the top of the pump is squeezed and the fluid returns to the abdominal reservoir, causing penile flaccidity.
13 Common Sex-Drive Killers
Obtaining erections which are either not rigid or full (lazy erection), or are lost more rapidly than would be expected (often before or during penetration), can be a sign of a failure of the mechanism which keeps blood held in the penis, and may signify an underlying clinical condition, often cardiovascular in origin.
Incidence and Prevalence
According to the National Ambulatory Medical Care Survey (NAMCS), approximately 22 out of every 1000 men in the United States sought medical attention for ED in 1999.
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The study was to be presented over the weekend at the annual meeting of the American Society of Gene Therapy, in Seattle.
Have more sex. Men who have sex at least once a week are 50 percent less likely to develop erectile dysfunction. Sex improves cardiovascular health, reduces stress, and may lower your risk of prostate cancer.